Loss of smell (anosmia) is a frequently
found symptom in Parkinson's disease. Moreover, numerous studies have
highlighted a significant incidence of cerebrovascular disease in patients with
Parkinson’s disease. The smell disorder has been framed as an indicator of a
sensory pathological process consistent with the hypothesis of the origin of
the disease from the peripheral and visceral nervous system, according to Braak
theory. In this study, we sought a correlation between vascular damage, a
possible contributing factor for 'central' type neurodegeneration, and anosmia
in a cohort of 118 patients with Parkinson’s disease of the outpatients’ clinic
for Movement Disorders. In this investigation we calculated the absolute and
relative percentages of the two considered parameters for the total population
and the subpopulations respectively; thereafter we performed the statistical
analysis for cerebrovascular disease and anosmia with the chi-square test,
which showed no correlation. This finding corroborates the idea of different
and independent mechanisms of pathogenic processes and compromises the symptom
anosmia as a unique marker or predictor of the disease.